Aorta Academy

SMDS (ACTA2 R179) and Cardiology

The Genetic Aortic Disorders Association Canada (GADA) and the John Ritter Foundation for Aortic Health (JRF), present the latest webinar in our ACTA2 series, featuring Dr. Angela Yetman, Pediatric and Adult Cardiologist, Children’s Hospital and Medical Center, Nebraska. Dr. Yetman has over 20 years of experience caring for patients with disorders of the aorta, including ACTA2. She has cared for multiple patients with SMDS since the before the genetic cause of the condition was identified.

Smooth muscle dysfunction syndrome (SMDS) is a rare autosomal dominant condition caused by specific pathogenic variants of ACTA2 gene that result in impaired smooth muscle contraction (variants altering the amino acid arginine 179). An early diagnosis of SMDS, multidisciplinary care and surveillance and timely management of symptoms are extremely important to reduce risk of complications, because of the severe involvement of the cardiovascular system. Join us to learn more from Dr. Yetman about multisystemic complications and cardiovascular care of this genetic condition.